Three years ago, a trial showed that inteferon-gamma 1b did not improve survival for patients with idiopathic pulmonary fibrosis [ref1]. A recent study evaluated safety and delivery of aerosol IFN-γ (100 μg 3 times/week) in 10 IPF patients using the I-neb. Although PFTs showed minimal change in FVC, and 6MW was unchanged, the
slope of (pre-therapy) decline in TLC and DLCO reversed after beginning therapy.
This eliminates the systemic effect of the drug. Further large study is needed to prove the efficacy of inhaled IFN-gamma for IPF.
References:
1. King TE Jr, Albera C, Bradford WZ, Costabel U, Hormel P, Lancaster L, Noble PW, Sahn SA, Szwarcberg J, Thomeer M, Valeyre D, du Bois RM; INSPIRE Study Group. Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial. Lancet. 2009 Jul 18;374(9685):222-8. Epub 2009 Jun 29. PubMed PMID: 19570573.
2. Diaz KT, Skaria S, Harris K, Solomita M, Lau S, Bauer K, Smaldone GC, Condos R. Delivery and Safety of Inhaled Interferon-γ in Idiopathic Pulmonary Fibrosis. J Aerosol Med Pulm Drug Deliv. 2012 Feb 23. [Epub ahead of print] PubMed PMID:22360317.
This eliminates the systemic effect of the drug. Further large study is needed to prove the efficacy of inhaled IFN-gamma for IPF.
References:
1. King TE Jr, Albera C, Bradford WZ, Costabel U, Hormel P, Lancaster L, Noble PW, Sahn SA, Szwarcberg J, Thomeer M, Valeyre D, du Bois RM; INSPIRE Study Group. Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial. Lancet. 2009 Jul 18;374(9685):222-8. Epub 2009 Jun 29. PubMed PMID: 19570573.
2. Diaz KT, Skaria S, Harris K, Solomita M, Lau S, Bauer K, Smaldone GC, Condos R. Delivery and Safety of Inhaled Interferon-γ in Idiopathic Pulmonary Fibrosis. J Aerosol Med Pulm Drug Deliv. 2012 Feb 23. [Epub ahead of print] PubMed PMID:22360317.
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