A recent study by Dr. Phan and associates of Michigan identified that FIZZ2 was highly induced in lungs of rodents with bleomycin-induced pulmonary fibrosis in vivo and of human patients with idiopathic pulmonary fibrosis. FIZZ2 expression was induced in rodent and human lung epithelial cells by Th2 cytokines in vitro.
FIZZ2 deficiency significantly attenuated pulmonary fibrosis in bleomycin model.
FiZZ2 is down stream of IL-13 signaling. It is unclear whether deletion of FIZZ2 abolishes IL-13 Th2 response.
Reference
[1] Liu, T., et al., J Immunol. 2011 May 20. [Epub ahead of print] PMID 21602491
FIZZ2 deficiency significantly attenuated pulmonary fibrosis in bleomycin model.
FiZZ2 is down stream of IL-13 signaling. It is unclear whether deletion of FIZZ2 abolishes IL-13 Th2 response.
Reference
[1] Liu, T., et al., J Immunol. 2011 May 20. [Epub ahead of print] PMID 21602491
No comments:
Post a Comment