Epithelial cell injury was believed a leading process to lung fibrosis. The injury includes reactive oxygen species (ROS), such as superoxide anion. Superoxide dismutase (SOD) catalyses the dismutation of superoxide anion to hydrogen peroxide. The rationale would be that an increase of SOD may reduce ROS, leading to less injury.
A team of Japanese scientists tested if inhalation of PC-SOD, compared with oral administration of pirfenidone, affects bleomycin-induced pulmonary fibrosis in a bleomycin-induced lung fibrosis model in mice. The authors concluded that PC-SOD suppressed the bleomycin-induced pulmonary inflammatory response and production of superoxide anions in the lung more effectively than pirfenidone.
Reference:
Tanaka KI, Azuma A, Miyazaki Y, Sato K, Mizushima T. Effects of lecithinized superoxide dismutase and/or pirfenidone against bleomycin-induced pulmonary fibrosis. Chest. 2012 Mar 29. [Epub ahead of print] PubMed PMID: 22459774.
A team of Japanese scientists tested if inhalation of PC-SOD, compared with oral administration of pirfenidone, affects bleomycin-induced pulmonary fibrosis in a bleomycin-induced lung fibrosis model in mice. The authors concluded that PC-SOD suppressed the bleomycin-induced pulmonary inflammatory response and production of superoxide anions in the lung more effectively than pirfenidone.
Reference:
Tanaka KI, Azuma A, Miyazaki Y, Sato K, Mizushima T. Effects of lecithinized superoxide dismutase and/or pirfenidone against bleomycin-induced pulmonary fibrosis. Chest. 2012 Mar 29. [Epub ahead of print] PubMed PMID: 22459774.
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