miR-21 was highly elevated in both animal models and in
human transplanted kidneys with nephropathy.
Deletion of miR-21 in mice resulted in no overt abnormality. However, miR-21 deficient mice showed a decrease in interstitial fibrosis in response to kidney injury.
The study found that peroxisome proliferator–activated receptor α (PPARα), a regulator of lipid metabolism, is a direct target of miR-21. Overexpression of PPARα in the kidney during injury inhibited fibrosis in mice; conversely, in mice that lacked PPARα, inhibition of miR-21 no longer protected against kidney fibrosis.
The study suggested that anti-miR to miR-21 may be beneficial to the patients with kidney fibrosis.
References:
Chau BN, Xin C, Hartner J, Ren S, Castano AP, Linn G, Li J, Tran PT, Kaimal V, Huang X, Chang AN, Li S, Kalra A, Grafals M, Portilla D, MacKenna DA, Orkin SH, Duffield JS. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med. 2012 Feb 15;4(121):121ra18. PubMed PMID: 22344686.
http://stm.sciencemag.org
Deletion of miR-21 in mice resulted in no overt abnormality. However, miR-21 deficient mice showed a decrease in interstitial fibrosis in response to kidney injury.
The study found that peroxisome proliferator–activated receptor α (PPARα), a regulator of lipid metabolism, is a direct target of miR-21. Overexpression of PPARα in the kidney during injury inhibited fibrosis in mice; conversely, in mice that lacked PPARα, inhibition of miR-21 no longer protected against kidney fibrosis.
The study suggested that anti-miR to miR-21 may be beneficial to the patients with kidney fibrosis.
References:
Chau BN, Xin C, Hartner J, Ren S, Castano AP, Linn G, Li J, Tran PT, Kaimal V, Huang X, Chang AN, Li S, Kalra A, Grafals M, Portilla D, MacKenna DA, Orkin SH, Duffield JS. MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways. Sci Transl Med. 2012 Feb 15;4(121):121ra18. PubMed PMID: 22344686.
http://stm.sciencemag.org
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